Mertk+ Liver Sinusoidal Endothelial Cells Negatively Regulate PINK1 Related Mitophagy and Accelerate MASH

ABSTRACT Background Mer tyrosine kinase (Mertk) regulating mitochondrial function of liver sinusoidal endothelial cells (LSECs) in metabolic dysfunction‐associated steatohepatitis (MASH) remains unclear. Methods Mertk/p‐Mertk, PINK1, and ERK/p‐ERK expression in steatotic LSECs and livers of MASH mic...

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Detalhes bibliográficos

Principais autores:	Yu‐Xuan Gao, Zhong Weng, Long Tang, Ming‐Yi Xu, Sheng‐Zheng Luo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-09-01
coleção:	Immunity, Inflammation and Disease
Assuntos:	extracellular regulated protein kinase (ERK) liver sinusoidal endothelial cell (LSEC) Mer tyrosine kinase (Mertk) metabolic dysfunction‐associated steatohepatitis (MASH) mitophagy PTEN‐induced putative kinase 1 (PINK1)
Acesso em linha:	https://doi.org/10.1002/iid3.70256
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