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Identification of actin mutants with neurodegenerative disease-like phenotypes via mutagenesis of the actin-ATP interface

Cofilin-actin rods are a well-documented stress response in neuronal cells and their persistence is frequently associated with neurodegenerative disease. However, the role of specific actin residues in promoting the formation of cofilin-actin rods and other anomalous cytoskeletal structures is large...

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Principais autores: Noah Mann, Keerthana Surabhi, Josephine Sharp, Mary Phipps, Maelee Becton, Jahiem Hill, Davis Roberts, Erzsebet M. Szatmari, Robert M. Hughes
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-06-01
Serier:Frontiers in Cellular Neuroscience
Fag:
neurodegeneration
cytoskeleton
cofilin-actin rods
Hirano bodies
Cry2/CIB1
cellular stress
Online adgang:https://www.frontiersin.org/articles/10.3389/fncel.2025.1543199/full
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