Identification of actin mutants with neurodegenerative disease-like phenotypes via mutagenesis of the actin-ATP interface

Cofilin-actin rods are a well-documented stress response in neuronal cells and their persistence is frequently associated with neurodegenerative disease. However, the role of specific actin residues in promoting the formation of cofilin-actin rods and other anomalous cytoskeletal structures is large...

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Autores principales:	Noah Mann, Keerthana Surabhi, Josephine Sharp, Mary Phipps, Maelee Becton, Jahiem Hill, Davis Roberts, Erzsebet M. Szatmari, Robert M. Hughes
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-06-01
Colección:	Frontiers in Cellular Neuroscience
Materias:	neurodegeneration cytoskeleton cofilin-actin rods Hirano bodies Cry2/CIB1 cellular stress
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1543199/full
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