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Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

Summary: Transcription activation domains (ADs) are inherently disordered proteins that often target multiple coactivator complexes, but the specificity of these interactions is not understood. Efficient transcription activation by yeast Gcn4 requires its tandem ADs and four activator-binding domain...

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Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Lisa M. Tuttle, Derek Pacheco, Linda Warfield, Jie Luo, Jeff Ranish, Steven Hahn, Rachel E. Klevit
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2018-03-01
Rangatū:Cell Reports
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124718303073
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