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Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA—Bulge Size and Sequence Dependence

In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides, nt) and sequences in the bulge formed upon bindin...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Merita Murtola, Alice Ghidini, Pasi Virta, Roger Strömberg
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2017-10-01
Schriftenreihe:Molecules
Schlagworte:
artificial ribonuclease
oligonucleotide
PNA
PNAzyme
phosphodiester cleavage
sequence selectivity
RNA bulge
Online-Zugang:https://www.mdpi.com/1420-3049/22/11/1856
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