siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy

Among tumor microenvironment (TME), the entire metabolic characteristics of tumor-resident cells are reprogrammed to benefit the expansion of tumor cells, which count on glutamine in large part to fuel the tricarboxylic acid cycle for energy generation and anabolic metabolism support. Endothelial ce...

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Bibliografische Detailangaben

Hauptverfasser:	Yunfei Yi, Zhangwen Peng, Yuanqi Liu, Huisong Hao, Liu Yu, Simin Wen, Shengjie Sun, Jianlin Shi, Meiying Wu, Lin Mei
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-04-01
Schriftenreihe:	Acta Pharmaceutica Sinica B
Schlagworte:	Glutaminolysis inhibition Tumor vascular normalization TAM repolarization Photo-immunotherapy Immunogenic cell death Immunosuppressive tumor microenvironment
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211383525000966
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