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A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors

Summary: Pancreatic cancer is the third leading cause of cancer-related death in the United States. Current chemotherapy options provide limited benefits. Emerging evidence suggests that a ketogenic diet (KD) exerts anti-tumor effects by reprogramming tumor metabolism and revealing therapeutic vulne...

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المؤلفون الرئيسيون: Omid Hajihassani, Asael Roichman, Jacob A. Boyer, Michal MacArthur, Ricardo Cordova, Alexander Loftus, Christina S. Boutros, Jonathan J. Hue, Parnian Naji, Soubhi Tahhan, Peter Gallagher, William Beegan, Danyal Shah, James Choi, Nimat Manzoor, Shihong Lei, Christine Kim, Moeez Rathore, Ishan Shah, Kevin Lebo, Helen Cheng, Anusha Mudigonda, Craig Hunter, Mehrdad Zarei, Sydney Alibeckoff, Karen Ji, Hallie Graor, Masaru Miyagi, Ali Vaziri-Gohar, Henri Brunengraber, Rui Wang, Peder J. Lund, Luke D. Rothermel, Joshua D. Rabinowitz, Jordan M. Winter
التنسيق: Artigo
اللغة:Inglês
منشور في: Elsevier 2026-05-01
سلاسل:Cell Reports Medicine
الموضوعات:
pancreatic cancer
ketogenic diet
glutamine metabolism
targeted therapy
chemotherapy
combination therapy
الوصول للمادة أونلاين:http://www.sciencedirect.com/science/article/pii/S2666379126001874
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