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In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm.

Differentiation of embryonic stem cells and induced pluripotent stem cells (iPSCs) into endoderm derivatives, including thyroid, thymus, lungs, liver, and pancreas, has broad implications for disease modeling and therapy. We utilize and expand a model development approach previously outlined by the...

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Hlavní autoři: Amirmahdi Mostofinejad, David A Romero, Dana Brinson, Thomas K Waddell, Golnaz Karoubi, Cristina H Amon
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2025-08-01
Edice:PLoS Computational Biology
On-line přístup:https://doi.org/10.1371/journal.pcbi.1013407
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