A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

Adoptive immunotherapy using TCR gene-modified T-lymphocytes is an attractive strategy for targeting malignancies. However, TCR mispairings between endogenous and introduced TCR chains are a major concern, as they may induce mixed TCRs with unknown specificities and may reduce the expression of ther...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Sachiko Okamoto, Yasunori Amaishi, Yumi Goto, Hiroaki Ikeda, Hiroshi Fujiwara, Kiyotaka Kuzushima, Masaki Yasukawa, Hiroshi Shiku, Junichi Mineno
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2012-01-01
Serier:	Molecular Therapy: Nucleic Acids
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2162253116301184
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!