A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

Adoptive immunotherapy using TCR gene-modified T-lymphocytes is an attractive strategy for targeting malignancies. However, TCR mispairings between endogenous and introduced TCR chains are a major concern, as they may induce mixed TCRs with unknown specificities and may reduce the expression of ther...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sachiko Okamoto, Yasunori Amaishi, Yumi Goto, Hiroaki Ikeda, Hiroshi Fujiwara, Kiyotaka Kuzushima, Masaki Yasukawa, Hiroshi Shiku, Junichi Mineno
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2012-01-01
Schriftenreihe:	Molecular Therapy: Nucleic Acids
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2162253116301184
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