Self-oxygenating PCN-224(Mn) co-delivers sorafenib and plumbagin to boost chemo-photodynamic therapy in hepatocellular carcinoma

Tumor hypoxia is a major barrier to oxygen-dependent photodynamic therapy (PDT), markedly limiting its therapeutic efficacy in hepatocellular carcinoma (HCC). Herein, a self‑oxygenating and redox-amplifying metal-organic framework (MOF) nanoplatform is constructed by co-loading sorafenib (Sor) and p...

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Detalhes bibliográficos

Principais autores:	Xiang Wang, Hengrui Li, Le Wang, Yihan Ma, Miao Qin, Ruonan Sun, Jing Hu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-06-01
Colecção:	International Journal of Pharmaceutics: X
Assuntos:	Hepatocellular carcinoma PCN-224(Mn) Photodynamic therapy Self‑oxygenation Chemotherapy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2590156726000745
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