Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial

Abstract We report on the utility of speech-based digital endpoints measured during a Phase 1b study of VRG50635 in Amyotrophic Lateral Sclerosis (ALS). Fifty-four participants with ALS were enrolled and participated in an 8-week pretreatment run-in, followed by three 8-week dosing periods and an 8-...

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Autori principali:	Michael Neumann, Hardik Kothare, Meredith Bartlett, Oliver Roesler, Christiane Suendermann-Oeft, Abhishek Hosamath, Lakshmi Arbatti, David Pautler, David Suendermann-Oeft, Diego Cadavid, Robert H. Scannevin, Ines Hoffmann, Anil Tarachandani, Tara Haley, Shane Raines, Philip Van Damme, Pentti Tienari, Eino Solje, Manu Jokela, Angela Genge, Colleen O’Connell, Ruben P. A. van Eijk, Leonard H. van den Berg, Vikram Ramanarayanan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-04-01
Serie:	Scientific Reports
Accesso online:	https://doi.org/10.1038/s41598-026-48100-6
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