Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial

Abstract We report on the utility of speech-based digital endpoints measured during a Phase 1b study of VRG50635 in Amyotrophic Lateral Sclerosis (ALS). Fifty-four participants with ALS were enrolled and participated in an 8-week pretreatment run-in, followed by three 8-week dosing periods and an 8-...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Michael Neumann, Hardik Kothare, Meredith Bartlett, Oliver Roesler, Christiane Suendermann-Oeft, Abhishek Hosamath, Lakshmi Arbatti, David Pautler, David Suendermann-Oeft, Diego Cadavid, Robert H. Scannevin, Ines Hoffmann, Anil Tarachandani, Tara Haley, Shane Raines, Philip Van Damme, Pentti Tienari, Eino Solje, Manu Jokela, Angela Genge, Colleen O’Connell, Ruben P. A. van Eijk, Leonard H. van den Berg, Vikram Ramanarayanan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-026-48100-6
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!