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Single-domain antibody-based protein degrader for synucleinopathies

Abstract Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, and treatments mainly focus on symptom management. In...

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Hlavní autoři: Yixiang Jiang, Yan Lin, Amber M. Tetlow, Ruimin Pan, Changyi Ji, Xiang-Peng Kong, Erin E. Congdon, Einar M. Sigurdsson
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-05-01
Edice:Molecular Neurodegeneration
On-line přístup:https://doi.org/10.1186/s13024-024-00730-y
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