Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions

Down syndrome (DS), caused by trisomy 21, is the most prevalent genetic condition associated with accelerated aging and near-universal development of early-onset Alzheimer’s disease (AD). Beyond gene-dosage imbalance, trisomy 21 induces widespread transcriptional, metabolic, and proteomic remodeling...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Eugenio Barone, Marzia Perluigi
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2026-04-01
Serija:	Antioxidants
Teme:	Down syndrome proteostasis oxidative stress mitochondrial dysfunction Alzheimer’s disease
Online dostop:	https://www.mdpi.com/2076-3921/15/4/520
Oznake:	Označite Brez oznak, prvi označite!