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Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions

Down syndrome (DS), caused by trisomy 21, is the most prevalent genetic condition associated with accelerated aging and near-universal development of early-onset Alzheimer’s disease (AD). Beyond gene-dosage imbalance, trisomy 21 induces widespread transcriptional, metabolic, and proteomic remodeling...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Eugenio Barone, Marzia Perluigi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2026-04-01
Schriftenreihe:Antioxidants
Schlagworte:
Down syndrome
proteostasis
oxidative stress
mitochondrial dysfunction
Alzheimer’s disease
Online-Zugang:https://www.mdpi.com/2076-3921/15/4/520
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