Multidimensional targeting of ischemia-reperfusion injury by genistein: from molecular crosstalk to clinical translation

Ischemia-reperfusion injury (IRI) is a convergent pathology driven by oxidative stress, sterile inflammation, mitochondrial dysfunction, and regulated cell death (apoptosis, necroptosis, pyroptosis, ferroptosis), yet validated pharmacotherapies remain scarce. Genistein, a soy-derived isoflavone phyt...

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Principais autores:	Ruihua Wang, Chunye Ya, Wei He, Yunjian Pan, Cunguo Shi, Yujing Lin, Xuekun Xing
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	apoptosis genistein inflammatory response ischemia-reperfusion injury oxidative stress pharmacokinetics
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1864013/full
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