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Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein

Abstract Artemisinin is an anti-malarial drug that has shown anticancer properties. Recently, ferroptosis was reported to be induced by dihydroartemisinin (DHA) and linked to iron increase. In the current study, we determined the effect of DHA in leukemic cell lines on ferroptosis induction and iron...

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Autori principali: E. Grignano, L. Cantero-Aguilar, Z. Tuerdi, T. Chabane, R. Vazquez, N. Johnson, J. Zerbit, J. Decroocq, R. Birsen, M. Fontenay, O. Kosmider, N. Chapuis, D. Bouscary
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2023-03-01
Serie:Cell Death Discovery
Accesso online:https://doi.org/10.1038/s41420-023-01371-8
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