Expression of DNA-damage response genes after exposure to high LET particles used in BNCT in glioblastoma cells with altered radiosensitivity

Abstract DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a central role in the repair of double-strand breaks (DSBs), but its deficiency alters the broader DNA damage response in glioblastoma cells exposed to α particle irradiation. Here, we investigated transcriptional changes in DN...

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Detalles Bibliográficos

Principais autores:	Martyna Araszkiewicz, Agnieszka Korgul, Katarzyna Tymińska, Urszula Kaźmierczak, Kinga Dyka, Patrycja Chuchała, Renata Grzela, Patrycja Kamińska, Roman Kuczma, Bohdan Paterczyk, Anna Stankiewicz-Drogoń, Beata Wielgus-Kutrowska, Agata Kustra, Michał Fryc, Piotr Bednarczyk, Kamila Maliszewska-Olejniczak
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-12-01
Series:	Scientific Reports
Assuntos:	Glioblastoma DNA-PKcs α particle irradiation DNA damage response Radiosensitivity
Acceso en liña:	https://doi.org/10.1038/s41598-025-32635-1
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