क्यूआर कोड

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

Disruption to protein homeostasis caused by lysosomal dysfunction and associated impairment of autophagy is a prominent pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). The most common genetic cause of ALS/FTD is a G4C2 hexanucleotide repeat expansion in C9orf72 (C9A...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Claudia S. Bauer, Christopher P. Webster, Allan C. Shaw, Jannigje R. Kok, Lydia M. Castelli, Ya-Hui Lin, Emma F. Smith, Francisco Illanes-Álvarez, Adrian Higginbottom, Pamela J. Shaw, Mimoun Azzouz, Laura Ferraiuolo, Guillaume M. Hautbergue, Andrew J. Grierson, Kurt J. De Vos
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2022-12-01
श्रृंखला:Frontiers in Cellular Neuroscience
विषय:
C9orf72
DPR
autophagy
ALS/FTD
TMEM106B
ऑनलाइन पहुंच:https://www.frontiersin.org/articles/10.3389/fncel.2022.1061559/full
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