Protection against isoproterenol-induced cardiac injury by sacubitril/valsartan is associated with upregulation of the alternative renin-angiotensin-aldosterone system pathway

Abstract Long-term stimulation of myocardial beta-receptors by isoproterenol is a well-established model of heart damage and failure. This study investigated the potential interactions of isoproterenol administration with the renin-angiotensin-aldosterone system (RAAS) and whether sacubitril/valsart...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Fedor Simko, Peter Stanko, Tomas Baka, Kristina Repova, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, Michaela Adamcova
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2026-05-01
Rangatū:	Scientific Reports
Ngā marau:	Isoproterenol-damaged heart Remodeling ARNI Protection Ang 1–7
Urunga tuihono:	https://doi.org/10.1038/s41598-026-52621-5
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!