Protection against isoproterenol-induced cardiac injury by sacubitril/valsartan is associated with upregulation of the alternative renin-angiotensin-aldosterone system pathway

Abstract Long-term stimulation of myocardial beta-receptors by isoproterenol is a well-established model of heart damage and failure. This study investigated the potential interactions of isoproterenol administration with the renin-angiotensin-aldosterone system (RAAS) and whether sacubitril/valsart...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Fedor Simko, Peter Stanko, Tomas Baka, Kristina Repova, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, Michaela Adamcova
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2026-05-01
Цуврал:	Scientific Reports
Нөхцлүүд:	Isoproterenol-damaged heart Remodeling ARNI Protection Ang 1–7
Онлайн хандалт:	https://doi.org/10.1038/s41598-026-52621-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!