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Pharmacological profiling of intravenous MP-04: sustained NAD+ augmentation, immune modulation, and renal protection in preclinical models

IntroductionSystemic inflammation and mitochondrial bioenergetic failure are central drivers of multi-organ dysfunction in advanced liver disease, sepsis, and acute kidney injury (AKI). Currently available therapies remain largely supportive and fail to directly address intracellular NAD+ depletion...

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Principais autores: Alip Ghosh, Gautham Pranesh, Nikhil Zachariah, Eisuke Murakami, Alonso Heredia, Poonam Mathur, Leigh Ann Burns-Naas, Steve Weng, Arvind Ramanathan, Shyam Kottilil, G. Mani Subramanian
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2026-06-01
סדרה:Frontiers in Pharmacology
נושאים:
acute kidney injury (AKI)
cytokine modulation
dihydronicotinamide riboside (NRH)
hepatorenal syndrome
immunomodulation
mitochondrial bioenergetics
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fphar.2026.1832979/full
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