Pharmacological profiling of intravenous MP-04: sustained NAD+ augmentation, immune modulation, and renal protection in preclinical models

IntroductionSystemic inflammation and mitochondrial bioenergetic failure are central drivers of multi-organ dysfunction in advanced liver disease, sepsis, and acute kidney injury (AKI). Currently available therapies remain largely supportive and fail to directly address intracellular NAD+ depletion...

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Autors principals:	Alip Ghosh, Gautham Pranesh, Nikhil Zachariah, Eisuke Murakami, Alonso Heredia, Poonam Mathur, Leigh Ann Burns-Naas, Steve Weng, Arvind Ramanathan, Shyam Kottilil, G. Mani Subramanian
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-06-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	acute kidney injury (AKI) cytokine modulation dihydronicotinamide riboside (NRH) hepatorenal syndrome immunomodulation mitochondrial bioenergetics
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1832979/full
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