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Characterization of motor and non-motor features associated with bilateral nigral degeneration due to A53T alpha-synuclein in female rats

Abstract Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra (SN), accumulation of alpha-synuclein (a-Syn)-rich aggregates, and the development of both motor and non-motor symptoms. The absence of a cure for PD underscores the critical need for anima...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Laura Kondrataviciute, Minesh Kapadia, Hien Chau, Cherisse Tan, Polly Ou, Ritisha Mukherjee, Sarah Hui, Sabika Jafri, Jimmy George, Ivan Skelin, Taufik Valiante, Luka Milosevic, Lorraine V. Kalia, Suneil K. Kalia
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2026-01-01
Rangatū:Scientific Reports
Ngā marau:
Parkinson’s disease
Alpha-synuclein
Non-motor behavior
Motor behavior
Depression
Rat Model
Urunga tuihono:https://doi.org/10.1038/s41598-025-34884-6
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