The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice

ObjectivesEpileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ1-42) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these Aβ1-42 olig...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Maxime Vande Vyver, Louise Daeninck, Gino De Smet, Najat Aourz, Surajit Sahu, Sebastiaan Engelborghs, Kris Pauwels, Dimitri De Bundel, Ilse Smolders
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-09-01
Schriftenreihe:	Frontiers in Aging Neuroscience
Schlagworte:	amyloid beta 1-42 oligomer Alzheimer’s disease epilepsy seizure
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1239140/full
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