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Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis

Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 pathogenicity in MS has been correlated with the dysreg...

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Main Authors: Constance C. Angelou, Alexandria C. Wells, Jyothi Vijayaraghavan, Carey E. Dougan, Rebecca Lawlor, Elizabeth Iverson, Vanja Lazarevic, Motoko Y. Kimura, Shelly R. Peyton, Lisa M. Minter, Barbara A. Osborne, Elena L. Pobezinskaya, Leonid A. Pobezinsky
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
EAE
CD4
miRNA
IL-1R1
IL-23R
CCR2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03125/full
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