Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis

Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 pathogenicity in MS has been correlated with the dysreg...

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Hlavní autoři:	Constance C. Angelou, Alexandria C. Wells, Jyothi Vijayaraghavan, Carey E. Dougan, Rebecca Lawlor, Elizabeth Iverson, Vanja Lazarevic, Motoko Y. Kimura, Shelly R. Peyton, Lisa M. Minter, Barbara A. Osborne, Elena L. Pobezinskaya, Leonid A. Pobezinsky
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-01-01
Edice:	Frontiers in Immunology
Témata:	EAE CD4 miRNA IL-1R1 IL-23R CCR2
On-line přístup:	https://www.frontiersin.org/article/10.3389/fimmu.2019.03125/full
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