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A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel

Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Fábio França, Patrícia M. A. Silva, José X. Soares, Ana C. Henriques, Daniela R. P. Loureiro, Carlos M. G. Azevedo, Carlos M. M. Afonso, Hassan Bousbaa
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-12-01
Schriftenreihe:Molecules
Schlagworte:
pyranoxanthone
antitumor
paclitaxel
mitosis
apoptosis
cancer
Online-Zugang:https://www.mdpi.com/1420-3049/25/24/5845
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