A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel

Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors...

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Principais autores:	Fábio França, Patrícia M. A. Silva, José X. Soares, Ana C. Henriques, Daniela R. P. Loureiro, Carlos M. G. Azevedo, Carlos M. M. Afonso, Hassan Bousbaa
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2020-12-01
Series:	Molecules
Assuntos:	pyranoxanthone antitumor paclitaxel mitosis apoptosis cancer
Acceso en liña:	https://www.mdpi.com/1420-3049/25/24/5845
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