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Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

Summary: Double homeobox (DUX) genes are unique to eutherian mammals, expressed transiently during zygotic genome activation (ZGA) and involved in facioscapulohumeral muscular dystrophy (FSHD) and cancer when misexpressed. We evaluate the 3 human DUX genes and the ancestral single homeobox gene sDUX...

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Autori principali: Darko Bosnakovski, Erik A. Toso, Elizabeth T. Ener, Micah D. Gearhart, Lulu Yin, Felipe F. Lüttmann, Alessandro Magli, Ke Shi, Johnny Kim, Hideki Aihara, Michael Kyba
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-10-01
Serie:iScience
Soggetti:
Developmental genetics
Molecular interaction
Molecular toxicology
Evolutionary developmental biology
Accesso online:http://www.sciencedirect.com/science/article/pii/S2589004223019004
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