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Construction of pseudorabies virus variant attenuated vaccine: codon deoptimization of US3 and UL56 genes based on PRV gE/TK deletion strain

Since 2011, pseudorabies based on the pseudorabies virus (PRV) variant has emerged as a serious health issue in pig farms in China. The PRV gE/TK or gE/gI/TK deletion strains protect against emerging PRV variants. However, these variants may cause lethal infections in newborn piglets without PRV ant...

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Principais autores: Mengwei Xu, Laixu Zhu, Aimin Ge, Yamei Liu, Saisai Chen, Ziwen Wei, Yating Zheng, Ling Tong, Zhisheng Wang, Rongmei Fei, Jichun Wang, Chuanjian Zhang
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2023-10-01
סדרה:Frontiers in Microbiology
נושאים:
pseudorabies virus
attenuation
immunogenicity
codon deoptimization
US3-S
UL56
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1248573/full
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