Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages

Silicosis is an occupational lung disease characterized by persistent inflammation and irreversible fibrosis. Crystalline silica (CS) particles are mainly phagocytized by alveolar macrophages (AMs), which trigger apoptosis, inflammation, and pulmonary fibrosis. Previously, we found that autophagy-ly...

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Главные авторы:	Xiu He, Shi Chen, Chao Li, Jiaqi Ban, Yungeng Wei, Yangyang He, Fangwei Liu, Ying Chen, Jie Chen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2020-01-01
Серии:	Cells
Предметы:	tfeb trehalose silicosis alveolar macrophages autophagy lysosome
Online-ссылка:	https://www.mdpi.com/2073-4409/9/1/122
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