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Current limitations in predicting mRNA translation with deep learning models

Abstract Background The design of nucleotide sequences with defined properties is a long-standing problem in bioengineering. An important application is protein expression, be it in the context of research or the production of mRNA vaccines. The rate of protein synthesis depends on the 5′ untranslat...

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Autori principali: Niels Schlusser, Asier González, Muskan Pandey, Mihaela Zavolan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-08-01
Serie:Genome Biology
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Accesso online:https://doi.org/10.1186/s13059-024-03369-6
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