Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment

Abstract Background The combinatorial effect of multiple genetic factors calculated as a polygenic risk score (PRS) has been studied to predict disease progression to Alzheimer’s disease (AD) from mild cognitive impairment (MCI). Previous studies have investigated the performance of PRS in the predi...

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Bibliografiske detaljer

Principais autores:	Jung-Min Pyun, Young Ho Park, Keon-Joo Lee, SangYun Kim, Andrew J. Saykin, Kwangsik Nho, for the Alzheimer’s Disease Neuroimaging Initiative
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2021-08-01
Serier:	Translational Neurodegeneration
Fag:	Polygenic risk score Mild cognitive impairment Alzheimer’s disease Disease progression APOE ε4
Online adgang:	https://doi.org/10.1186/s40035-021-00259-w
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