Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Abstract Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical industry are however high production costs, long processing times and low productivities associated with their producti...

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Autori principali:	Yanyan Wang, Xiaowei Li, Xin Chen, Jens Nielsen, Dina Petranovic, Verena Siewers
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-07-01
Serie:	Microbial Cell Factories
Soggetti:	Pharmaceutical proteins Saccharomyces cerevisiae Protein secretion capacity RNA-seq analysis
Accesso online:	https://doi.org/10.1186/s12934-021-01624-0
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