Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Abstract Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical industry are however high production costs, long processing times and low productivities associated with their producti...

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Bibliografiske detaljer

Principais autores:	Yanyan Wang, Xiaowei Li, Xin Chen, Jens Nielsen, Dina Petranovic, Verena Siewers
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2021-07-01
Serier:	Microbial Cell Factories
Fag:	Pharmaceutical proteins Saccharomyces cerevisiae Protein secretion capacity RNA-seq analysis
Online adgang:	https://doi.org/10.1186/s12934-021-01624-0
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