Glutathione Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum Stress and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells

Histone deacetylase inhibitors (HDACi) are emerging as anti-hepatocellular carcinoma (HCC) agents. However, the molecular mechanisms underlying HDACi-induced sensitization to oxidative stress and cell death of HCC remain elusive. We hypothesized that HDACi reduces the anti-oxidative stress capacity...

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Bibliographic Details

Main Authors:	Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2021-09-01
Series:	Antioxidants
Subjects:	GPX8 HCC ER stress HDACi oxidative stress apoptosis
Online Access:	https://www.mdpi.com/2076-3921/10/10/1503
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