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Glutathione Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum Stress and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells

Histone deacetylase inhibitors (HDACi) are emerging as anti-hepatocellular carcinoma (HCC) agents. However, the molecular mechanisms underlying HDACi-induced sensitization to oxidative stress and cell death of HCC remain elusive. We hypothesized that HDACi reduces the anti-oxidative stress capacity...

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Principais autores: Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-09-01
Serier:Antioxidants
Fag:
GPX8
HCC
ER stress
HDACi
oxidative stress
apoptosis
Online adgang:https://www.mdpi.com/2076-3921/10/10/1503
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