ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis

Oxidative disruption of dopaminergic neurons is regarded as a crucial pathogenesis in Parkinson's disease (PD), eventually causing neurodegenerative progression. (-)-Clausenamide (Clau) is an alkaloid isolated from plant Clausena lansium (Lour.), which is well-known as a scavenger of lipid peroxide...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kun Li, Meng Wang, Zi-Han Huang, Min Wang, Wan-Yang Sun, Hiroshi Kurihara, Rui-Ting Huang, Rong Wang, Feng Huang, Lei Liang, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-07-01
Schriftenreihe:	Pharmacological Research
Schlagworte:	Parkinson's disease (-)-Clausenamide 5-Lipoxygenase Lipid peroxides Ferroptosis Oxidative damage
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1043661823001354
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!