Endogenous retroviruses and response to immune checkpoint inhibitors: mechanisms, clinical evidence, and therapeutic implications

Endogenous retroviruses (ERVs) are epigenetically silenced remnants of ancient retroviral integrations that comprise ~8% of the human genome. In cancer, DNA hypomethylation and chromatin remodeling—spontaneously or induced by epigenetic therapies—can derepress ERV loci, leading to abundant ERV-deriv...

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Principais autores:	Fanyuan Wu, Quezhu Danzeng, Runxi Wu, Yi Shen, Guang Shi
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-05-01
Serija:	Frontiers in Immunology
Teme:	endogenous retroviruses epigenetic regulation immune checkpoint inhibitors tumor microenvironment viral mimicry
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1835325/full
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