Enhancement of effector functions of anti-CD20 monoclonal antibody by increased afucosylation in CHO cell line through cell culture medium optimization

Abstract Background Recombinant therapeutic anti-CD20 monoclonal antibody (mAb) is used for the treatment of non-Hodgkin’s lymphoma, a common B cell lymphoma constituting 80% of all lymphomas. Anti-CD20 mAb contains an Fc-linked biantennary glycan. Although, anti-CD20 monoclonal antibodies are being...

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Hlavní autoři:	Bala Reddy Bheemareddy, Prakash Narayana Reddy, Kranthi Vemparala, Vijaya R. Dirisala
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2022-10-01
Edice:	Journal of Genetic Engineering and Biotechnology
Témata:	Non-Hodgkin’s lymphoma Anti-CD20 monoclonal antibody Chinese hamster ovary cells Afucosylation Osmolality Antibody-dependent cellular cytotoxicity
On-line přístup:	https://doi.org/10.1186/s43141-022-00421-5
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