Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

Microtubule (MT) associated protein tau is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs), which manifest as neurofibrillary tangles (NFTs) in the brains of individuals with Alzheimer’s disease (AD) and related tauopathies. Hyperphosphorylation and truncation of t...

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מידע ביבליוגרפי

Principais autores:	Yan Zhou, Jianhua Shi, Dandan Chu, Wen Hu, Zongyu Guan, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2018-02-01
סדרה:	Frontiers in Aging Neuroscience
נושאים:	Alzheimer’s disease tau hyperphosphorylation truncation tau pathogenesis
גישה מקוונת:	http://journal.frontiersin.org/article/10.3389/fnagi.2018.00027/full
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