Association between lower body temperature and increased tau pathology in cognitively normal older adults

Background: Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in Alzheimer's Disease (AD). Tau phosphorylation is substantially increased by a small (<1 °C) decrease in temperature within the human ph...

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Detalhes bibliográficos

Principais autores:	Esther M. Blessing, Ankit Parekh, Rebecca A. Betensky, James Babb, Natalie Saba, Ludovic Debure, Andrew W. Varga, Indu Ayappa, David M. Rapoport, Tracy A. Butler, Mony J. de Leon, Thomas Wisniewski, Brian J. Lopresti, Ricardo S. Osorio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-09-01
coleção:	Neurobiology of Disease
Assuntos:	Tau Phosphorylation Body temperature Aging Alzheimer's disease Neurofibrillary tangle
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996122001401
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