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Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives

Abstract The BraSR two-component system plays a crucial role in bacitracin sensing and resistance in Staphylococcus aureus, making the BraS histidine kinase an attractive antibacterial target. In this study, we applied a structure-based drug discovery approach to identify ATP competitive isatin and...

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Main Authors: Grijesh Jaiswal, Sandesh Telang, Tripti Shrivastava, Shantu Amin, Arun K. Sharma, Krishne Gowda, Sandeep Kumar Srivastava
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-04-01
Series:Scientific Reports
Subjects:
MRSA
BraS histidine kinase
Isatin
Indazole
Molecular dynamics
MM-PBSA
Online Access:https://doi.org/10.1038/s41598-026-49362-w
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