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Similar requirement for clathrin in EGF- and HGF- stimulated Akt phosphorylation

Receptor tyrosine kinases, such as the epidermal growth factor (EGF) receptor (EGFR) and Met lead to activation of intracellular signals including Akt, a critical regulator of cell survival, metabolism and proliferation. Upon binding their respective ligands, each of these receptors is recruited int...

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Autori principali: Stefanie Lucarelli, Rohan Pandey, Gurjeet Judge, Costin N. Antonescu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2016-05-01
Serie:Communicative & Integrative Biology
Soggetti:
clathrin
endocytosis
membrane traffic
phosphorylation
receptor tyrosine kinase
signaling adaptor
signaling scaffold
signaling microdomain
TIRF microscopy
Accesso online:http://dx.doi.org/10.1080/19420889.2016.1175696
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