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AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells

BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes. Here, we determined the anti-HCC efficacy of AZD5153, a potent...

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Principais autores: Cho-Hao Lin, Jimmy Chun-Tien Kuo, Ding Li, Aaron B. Koenig, Alexander Pan, Pearlly Yan, Xue-Feng Bai, Robert J. Lee, Kalpana Ghoshal
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-03-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
HCC
BRD4 (bromodomain-containing protein 4)
AZD5153
NAPRT
ChIP-seq
nanoemulsion
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2022.853652/full
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