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AZD5153 enhances the chemo-sensitivity of gemcitabine on pancreatic cancer cells in vitro and in vivo

Abstract Background Pancreatic cancer is a malignant disease with a poor prognosis. Gemcitabine (GEM), the first-line treatment drug, shows limited efficacy because of the notorious drug resistance of pancreatic cancer. Therefore, the development of sensitive drugs for pancreatic cancer is essential...

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Principais autores: Haixin Zhu, Minmin Shen, Yiqian Zhu, Ruoqi Wang, Rong Dong, Yuyu Huang, Lulin Zhu, Ying Li, Youyou Yan, Jiang Lou, Bo Zhang, Nengming Lin, Biqin Tan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-08-01
Serier:Cancer Cell International
Fag:
AZD5153
Gemcitabine
Pancreatic cancer
ERK/mTOR signaling
MUC2
Online adgang:https://doi.org/10.1186/s12935-025-03952-2
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