Integrating lymphovascular and perineural invasion into TNM staging: a novel ITNM system for enhanced prognostic stratification in colorectal cancer

BackgroundThe standard TNM staging system for colorectal cancer (CRC) fails to reflect true tumor biology because it ignores key histopathologic features such as lymphovascular and perineural invasion. We therefore developed and validated an “ITNM” classification that folds these two factors into th...

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Autors principals:	Jiaqi Hu, Minghao Zhang, Yang Qi, Yun Wang, Dalin Xu, Kejin Zhu, Jun Bu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-01-01
Col·lecció:	Frontiers in Oncology
Matèries:	colorectal cancer lymphovascular invasion perineural invasion prognosis model TNM staging
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1745324/full
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