Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau protein in neurons, which could help in future identif...

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Detalhes bibliográficos

Principais autores:	Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2021-06-01
coleção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-021-02272-1
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